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RNAseq of parental and neratinib resistant 5637 and OVCAR8 cells with or withour neratinib treatment

ABSTRACT: Pan-HER TKI neratinib has demonstrated clinical activity in patients with HER2-mutant cancers. However responses are heterogenoeus and not generally prolonged, suggesting de-novo and acquired resistance to neratinib. To study mechanisms of resistance to neratinib we generated neratinib resistant cells by gradual dose escalation until resistance was achieved and performed various analyses including RNAseq.

ORGANISM(S): Homo sapiens

PROVIDER: GSE128730 | GEO | 2020/01/07

REPOSITORIES: GEO

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RNAseq of parental and neratinib resistant 5637 and OVCAR8 cells with or withour neratinib treatment

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