Expression data from 15-day-old mouse testes

ABSTRACT: Activation of the Heat Shock Factor 1 (HSF1) in spermatogenic cells leads to apoptosis and infertility of males. To elucidate a mechanisms of apoptosis induced by HSF1 we generated transgenic mice expressing mutated, constitutively active human HSF1 (with a deletion of amino acids 221–315) specifically in spermatocytes (under control of the rat Hspa2 promoter). We carried out genome-wide transcriptional analyses in testes of control, wild-type, and transgenic males. Genes that changed the expression due to activation of HSF1 have been identified.

ORGANISM(S): Mus musculus

PROVIDER: GSE128996 | GEO | 2019/03/29

REPOSITORIES: GEO