YAP and AP-1 cooperate to initiate rapid pancreatic cancer development from the ductal cell population in mice

ABSTRACT: Purpose: We aimed to elucidate the unique consequences of YAP/TAZ activation in pancreatic ductal cells. Methods: We isolated RNA from Lats1 and Lats2 double knockout ductal cells from Lats1fl/fl; Lats2fl/fl; Sox9-CreER mice. Results: Oncogenic activation of YAP in ductal cells lead to the rapid development of carcinoma in situ with microinvasion.

ORGANISM(S): Mus musculus

PROVIDER: GSE129045 | GEO | 2020/09/17

REPOSITORIES: GEO