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Next Generation Sequencing identifies lymph node lymphatic endothelial cell genes regulated by RANKL

ABSTRACT: Purpose: The objective was to identify genes regulted by RANK signalling in lymph node lymphatic endothelial cells Method: Lymphatic endothelial cells were FACS sorted from peripheral lymph nodes of mice deficient for stromal RANKL (Ccl19 Cre Rankl flox/flox) versus littermate controls (Rankl flox/flox) and processed for bulk RNA sequencing Results: Upregulated and downregulated genes were identified

ORGANISM(S): Mus musculus

PROVIDER: GSE129315 | GEO | 2019/06/01

REPOSITORIES: GEO

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Next Generation Sequencing identifies lymph node lymphatic endothelial cell genes regulated by RANKL

Project description:Next Generation Sequencing identifies lymph node lymphatic endothelial cell genes regulated by RANKL

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Transcription profiling of human lymphatic endothelial cells, mouse dermal cells and human skin cells reveals an inflammation-induced mechanism for leukocyte transmigration of lymphatic vessel endothelium.

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