RXRs are required for neonatal expansion of the serosal macrophage pool and contribute to ovarian cancer progression

ABSTRACT: Distinct macrophage populations throughout the body display highly heterogeneous transcriptional and epigenetic programs. However, the regulation of chromatin accessibility of tissue-resident macrophages is poorly understood. In this study, we generated a data set for genome-wide transposase-accessible chromatin analysis (ATAC-seq) of large peritoneal macrophages in animals with myeloid-specific double deletion of the nuclear receptors RXRa and RXRb.

ORGANISM(S): Mus musculus

PROVIDER: GSE129414 | GEO | 2020/03/02

REPOSITORIES: GEO