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Avidity Selection of Natural Killer Response to MCMV

ABSTRACT: Natural killer (NK) cells are innate lymphocytes that possess features of adaptive immunity, such as the ability to recognize specific antigen, among others. In MCMV infection, the engagement of a subset of NK cells expressing an activating receptor Ly49H with MCMV-derived glycoprotein m157 results in a clonal-like expansion and the generation of a small pool of long-lived memory cells with higher Ly49H expression than the naive Ly49H-expressing NK cell pool. In this study, we interrogate the transcriptional differences between NK cells that express high verus low levels of Ly49H early after infection.

ORGANISM(S): Mus musculus

PROVIDER: GSE129490 | GEO | 2019/04/09

REPOSITORIES: GEO

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