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Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis

ABSTRACT: This study identifies molecular changes in hematopoietic stem cells (HSC) isolated from mice with chronic autoimmune arthritis induced using the collagen-induced arthritis (CIA) model.

ORGANISM(S): Mus musculus

PROVIDER: GSE129511 | GEO | 2019/05/01

REPOSITORIES: GEO

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Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis.

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Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis

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Project description:The aim of the project is to analyze the plasma proteomic profile of an animal model of arthritis (Collagen Induced Arthritis; CIA) in response to different treatments. For this, plasma samples from mice under five different treatments were analyzed (N=6 per group): Vehicle, CIA, CIA + Δ9-THCA-A (20 mg / kg), CIA + Δ9-THCA-A (20 mg / kg) + T0070907 (5 mg / kg) and CIA + Δ9-THCA-A (20 mg / kg) + SR141716A (5 mg / kg).

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Project description:We report the application of Agilent technology for high-throughput profiling of the post-transcriptome of the rheumatoid arthritis (RA) rat model induced by collagen type II (CIA), with acupuncture, Methotrexate, Isofluorane anesthetic and placebo treatments, as well as the healthy control.

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