The expression profiling of the early stage of multiple system atrophy model mice

ABSTRACT: Global transcriptional analysis of the brain of multiple system atrophy model mice after synuclein induction by tamoxifen. Multiple system atrophy (MSA) is pathologically characterized by accumulation of phosphorylated α-synuclein in the oligodendrocytes. The pathophisiological mechinism under the early staige of disease pregression has been unknown. To clarify molecular alteration just after α-synuclein overexpression in the oligodendrocytes, we performed whole transcriptome analysis of the brain obtained from MSA model mice and control at 10 days after α-synuclein induction.

ORGANISM(S): Mus musculus

PROVIDER: GSE129531 | GEO | 2021/06/01

REPOSITORIES: GEO