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Reverse gene-environment interaction approach to identify variants influencing body mass index in humans

ABSTRACT: Here we derive candidate gene-environment interaction (GxE) variants from promoter-enhancer interacting regions that respond to dietary fatty acid challenge through altered chromatin accessibility in human primary adipocytes, and demonstrate that molecular genomics data produced in physiologically relevant contexts can illuminate new functional GxE mechanisms in humans and identify variants for GxE testing in large biobanks.

ORGANISM(S): Homo sapiens

PROVIDER: GSE129574 | GEO | 2019/06/17

REPOSITORIES: GEO

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