Free circular introns with an unusual branchpoint in neuronal projections

ABSTRACT: In eukaryotic cells, most introns are degraded soon after splicing in the nucleus but some persist either due to lack of splicing (detained/retained introns) or because they contain important functional elements, for example, sno/scaRNAs. Few introns are detectable outside the nucleus. To hunt for interesting new phenomena in cytoplasmic introns and splicing, we conducted a multimodal study of total RNA within projections (axons, dendrites, glial projections) of rat hippocampal neurons and discovered a class of free circular introns enriched in distal projections.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE129924 | GEO | 2019/04/18

REPOSITORIES: GEO