Single-cell RNA-sequencing analysis of the IL-10 dependent response of human CD14+ monocytes to LPS

ABSTRACT: Inflammatory bowel diseases (IBD) involve dysregulated immune responses. Understanding the cellular specificity and compartmentalisation of cytokine responses may help to target cytokine therapies. Intestinal inflammation involves influx of CD14+ monocytes into the lamina propria of the gut where they can adopt pro-inflammatory phenotypes. In the healthy intestine, IL-10 plays a key role in controlling inflammation and promoting homeostasis. This data was generated to investigate the phenotypes that CD14+ monocytes can adopt following LPS stimulation with or without concominant IL-10 signaling blockade.

ORGANISM(S): Homo sapiens

PROVIDER: GSE130070 | GEO | 2020/08/01

REPOSITORIES: GEO