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TFE3 Xp11.2 translocation renal cell carcinoma mouse model

ABSTRACT: Renal Cell Carcinoma (RCC) associated with Xp11.2 translocation (TFE3-RCC) has been recently defined as a distinct subset of RCC. The Xp11 translocations involve the TFE3 transcription factor and produce chimeric TFE3 proteins retaining the basic helix-loop-helix leucine zipper structure for dimerization. To facilitate the development of molecular-based diagnostic tools and targeted therapies for TFE3-RCC, we generated a translocation RCC mouse model and performed DNA microarray analysis.

ORGANISM(S): Mus musculus

PROVIDER: GSE130072 | GEO | 2019/04/20

REPOSITORIES: GEO

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