Dataset Information

Expression data of GTSE1-knockdown hepatoma cell line Bel-7404

ABSTRACT: Liver cancer is the fourth deadliest cancer worldwide and is in lack of prognostic indicators. As a p53 inducible gene, GTSE1 (G2 and S phase-expressed-1) showed widely correlation with tumor progress and prognosis in clinical, while its potency as a prognosis indicator or molecular mechanism in regulating cell cycle remain little known. This study aimed to elucidate clinical values and potential functions of GTSE1 in liver cancer. In study of GTSE1 functions, Bel-7404 cell, a human hepatoma cell line, was induced GTSE1-knockdown using lentiviral-mediated RNAi and performed RNA microarray analysis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE130083 | GEO | 2019/04/20

REPOSITORIES: GEO

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Project description:Baicalein, a purified flavonoid compound with defined chemical structure extracted from the dry roots of Scutellaria radix that is a broadly used herb in China, has been proved to possess significant anti-hepatoma activity by inhibiting cell proliferation, invasion, metastasis and inducing apoptosis, autophagy via several cancer-related signaling molecules. In recent years, emerging studies have demonstrated that Chinese medicinal herbs can exert their anti-tumor effects through targeting lncRNAs，such as curcumin, camptothecin, resveratrol，paclitaxel. However, there is still no related report about the effects of baicalein on lncRNA expression profile when it exerts its inhibition on hepatoma tumor growth. To investigate whether the antitumor effect of baicalein is related to its modulation of lncRNA expression in hepatocellular carcinoma (HCC), we profiled the lncRNA expression in HCC cell line Bel-7402 treated with baicalein (0, 40, 80μM) for 24 hours using lncRNA microarray and detected the changes by comparing the lncRNA expression profile of HCC cell line Bel-7402 treated with baicalein (40 and 80 μM) and its DMSO control (0 μM). These findings suggest that modulation of lncRNA expression may be an important mechanism underlying the anti-hepatoma effects of baicalein and lay the groundwork for further investigations. To investigate whether the antitumor effect of baicalein is related to its modulation of lncRNA expression in hepatocellular carcinoma (HCC), we profiled the miRNA expression in HCC cell line Bel-7402 treated with baicalein (0, 40, 80μM) for 24 hours using miRNA microarray and detected the changes by comparing the lncRNA expression profile of HCC cell line Bel-7402 treated with baicalein (40 and 80 μM) and its DMSO control (0 μM). These findings suggest that modulation of lncRNA expression may be an important mechanism underlying the anti-hepatoma effects of baicalein and lay the groundwork for further investigations.

Dataset Information

Expression data of GTSE1-knockdown hepatoma cell line Bel-7404

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