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Identification of the pharmacological effects of Chrysanthemum morifolium Ramat. leaves extracts on high-fat diet induced obese mice through lipid-, and glucose metabolism

ABSTRACT: We investigated that ethanol extracts of Chrysanthemum morifolium Ramat. leaves improved metabolic disease on high-fat diet induced obese mice using metabolic profiling of lipid-, glucose, inflammation and RNA-seq transcriptomic profling.

ORGANISM(S): Mus musculus

PROVIDER: GSE130218 | GEO | 2019/04/24

REPOSITORIES: GEO

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Identification of the pharmacological effects of Chrysanthemum morifolium Ramat leaves extracts on high-fat diet induced obese mice through lipid profiling

Project description:We investigated anti-obesity mechanism of Chrysanthemum morifolium Ramat leaves extracts on high-fat diet induced obese mice using lipid profiling and RNA-seq transcriptomic profling.

2020-11-16 | GSE124777 | GEO

Identification of the pharmacological effects of Chrysanthemum morifolium Ramat leaves extracts on high-fat diet induced obese mice through lipid profiling

Project description:Identification of the pharmacological effects of Chrysanthemum morifolium Ramat leaves extracts on high-fat diet induced obese mice through lipid profiling

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Identification of the pharmacological effects of Chrysanthemum morifolium Ramat. leaves extracts on high-fat diet induced obese mice through lipid-, and glucose metabolism

Project description:Identification of the pharmacological effects of Chrysanthemum morifolium Ramat. leaves extracts on high-fat diet induced obese mice through lipid-, and glucose metabolism

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Proteomes and Histone Crotonylation Analysis Reveals the Importance of Crotonylation Low Temperature in Chrysanthemum

Project description:Chrysanthemum is a garden plant with good economic benefit and high ornamental value. Chrysanthemum in the key period of flowering in autumn and winter, vulnerable to cold damage, affecting the normal growth of the chrysanthemum plant and even death. little is known regarding the study of histone crotonylation in plant cold response. In this study, we first obtained reference chrysanthemum transcriptome data via RNA sequencing. Next, we quantitatively investigated the chrysanthemum proteome, crotonylation, and the association between them in chrysanthemum following low temperature. In total, 365669 unigenes, 6693 proteins and 2017 crotonylation sites were quantified under low temperature stress. There were 24631 up-regulated and 22648 down-regulated unigenes (absolute log2-fold change > 1 and P value<0.05), 393 up-regulated and 500 down-regulated proteins using a 1.2-fold threshold (P<0.05). The lysine crotonylation mainly influenced in photosynthesis, ribosome, antioxidant enzyme and ROS system. In the process of low temperature, 61 lysine crotonylation sites in 89 proteins were up-regulated and 87 lysine crotonylation sites in 72 proteins are down-regulated (1.2-fold threshold, P<0.05).

2021-01-04 | PXD010297 | Pride

Comparative analysis of chrysanthemum transcriptome in response to infection of three viruses: Cucumber mosaic virus, Tomato spotted wilt virus, and Potato virus X

Project description:Gene expression analysis of chrysanthemum infected with three different viruses including Cucumber mosaic virus, Tomato spotted wilt virus, and Potato virus X have been performed using the chrysanthemum 135K microarray. Mock and each virus infected chrysanthemum plants were subjected for microarray analysis.

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Comparative analysis of chrysanthemum transcriptome in response to infection of three viruses: Cucumber mosaic virus, Tomato spotted wilt virus, and Potato virus X

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Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and transgenic DgWRKY5 Chrysanthemum Transcriptomes

Project description:We generated 12 Gb of high-quality sequencing data (~6 Gb per sample) to clarify the molecular mechanism of salt tolerance between wild tipe and transgenic DgWRKY5 chrysanthemum under normal condition. A total of 1078 differentially expressed genes (DEGs) (593 up-regulated and 485 down-regulated) were identified between CK and DgWRKY5, including genes encoding transcription factors and protein kinases. We identified numerous differentially expressed genes that exhibited distinct expression patterns, and stress-related genes that were highly differentiated in wild tipe and transgenic DgWRKY5 chrysanthemum. These genes have known or potential roles in stress tolerance relative and were enriched in functional gene categories potentially responsible for chrysanthemum resistance. Therefore, they are appealing candidates for further investigation of the gene expression and associated regulatory mechanisms related to stress response .

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Project description:According to our study, Chrysanthemum lavandulifolum extract showed excellent antibiotic effects on Escherichia coli O157:H7. A notable point is that the antibiotic efficacy of the herb extract is on the all three proven targets for main antibiotic drugs that are bacterial cell wall biosynthesis, bacterial protein synthesis and bacterial DNA replication and repair. This multi-target efficacy of the herbal antibiotics may be used as more effective and safe drugs that substitute existing antibiotics.

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Project description:Chrysanthemum Raw sequence reads

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