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EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE130231 | GEO | 2019/07/15

REPOSITORIES: GEO

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EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells.

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EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells (ChIP-Seq)

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EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells (RNA-Seq)

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GPIF constrains Polycomb Repressive Complex 2 activity in germ cells

Project description:The project aimed at identifying the cofactors regulating Polycomb complex PRC2 enzymatic activity in gonads. We used a knock-in mouse model where the enzymatic subunit of PRC2 (either EZH2 or EZH1) is tagged (Flag-tag) to purify PRC2 from mouse adult testis. This experiment revealed the existence of a new cofactor for PRC2 that we called GPIF (AU022751).

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EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells

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EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells (ChIP-Seq)

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LATS2 regulates repressive epigenetic integrity via regulation of Polycomb repressive complex 2

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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