The RNA hairpin binder TRIM71 modulates alternative splicing by repressing Mbnl1

ABSTRACT: We demonstrate that global effects of TRIM71 on the cellular transcriptome of mouse embryonic stem cells (mESCs) are largely attributable to its RNA binding activity, and map the transcriptome-wide targets of wild-type TRIM71, NHL domain mutant TRIM71, and RING domain mutant TRIM71.

ORGANISM(S): Mus musculus

PROVIDER: GSE130248 | GEO | 2019/08/01

REPOSITORIES: GEO