Examining the role of ATRX-RNA interactions in ATRX and PRC2 localization and gene expression.

ABSTRACT: We disrupted the RNA binding region in endogenous ATRX and tested localization of ATRX, EZH2 and H3K27me3 by CUT&RUN. We show that ATRX-RNA binding is important to regulate ATRX and PRC2 localization to specific genes.

ORGANISM(S): Mus musculus

PROVIDER: GSE130452 | GEO | 2020/02/24

REPOSITORIES: GEO