Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

AVEN is an indirectly druggable mediator of neuroblastoma cell tumorigenicity and chemotherapy resistance

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE130524 | GEO | 2023/07/30

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

AVEN is an indirectly druggable mediator of neuroblastoma cell tumorigenicity and chemotherapy resistance [microarray]

Project description:Approximately half of children diagnosed with neuroblastoma have aggressive high-risk disease, against which current multimodal therapy has little success. New targets for therapeutic intervention are urgently needed. In a systems approach, we combined time-resolved mRNA-Seq with miRNA profiling in a model of neuroblastoma differentiation treated with or without the clinically approved histone deacetylase inhibitor, panobinostat. Treatment most strongly regulated miR-630, which strongly downregulated AVEN, an inhibitor of apoptosis. Here we characterized AVEN for the first time in neuroblastoma pathogenesis, disclosed its epigenetic regulation and discovered correlations between AVEN expression and resistance to chemotherapy. High-level AVEN expression in 649 primary neuroblastomas negatively correlated with patient survival. Stably enforcing AVEN expression in BE(2)-C cells markedly promoted growth as subcutaneous xenografts in mice, while CRISP/Cas9-mediated AVEN knockout in BE(2)-C cells substantially reduced xenograft growth and enhances the efficacy of systemic doxorubicin treatment. Cell-based assays, flow cytometric cell cycle analyses and SILAC experiments demonstrate that AVEN is required for neuroblastoma proliferation.

2023-07-30 | GSE130523 | GEO

AVEN is an indirectly druggable mediator of neuroblastoma cell tumorigenicity and chemotherapy resistance [RNA-seq]

2023-07-30 | GSE130520 | GEO

AVEN is an indirectly druggable mediator of neuroblastoma cell tumorigenicity and chemotherapy resistance

Project description:AVEN is an indirectly druggable mediator of neuroblastoma cell tumorigenicity and chemotherapy resistance

| PRJNA540517 | ENA

AVEN is an indirectly druggable mediator of neuroblastoma cell tumorigenicity and chemotherapy resistance [microarray]

Project description:AVEN is an indirectly druggable mediator of neuroblastoma cell tumorigenicity and chemotherapy resistance [microarray]

| PRJNA540518 | ENA

AVEN is an indirectly druggable mediator of neuroblastoma cell tumorigenicity and chemotherapy resistance [RNA-seq]

Project description:AVEN is an indirectly druggable mediator of neuroblastoma cell tumorigenicity and chemotherapy resistance [RNA-seq]

| PRJNA540519 | ENA

SSEA4 is a marker for chemotherapy resistance

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-11-19 | E-GEOD-57705 | biostudies-arrayexpress

Expression profiles of human osteoblasts directly and indirectly damaged by chemotherapy

Project description:This SuperSeries is composed of the SubSeries listed below.

2010-09-30 | GSE17860 | GEO

IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-05-31 | GSE181582 | GEO

SSEA4 is a marker for chemotherapy resistance

Project description:This SuperSeries is composed of the SubSeries listed below.

2015-11-19 | GSE57705 | GEO

Genome methylation defines EZH2 inhibitor resistance in neuroblastoma

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-08-01 | GSE143714 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data