Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia

ABSTRACT: We report here an efficient, reproducible model of T-cell leukemia in which lentiviral transduction of normal human cord blood yields aggressive leukemia that appears indistinguishable from natural disease. We utilize this synthetic model to uncover a role for oncogene-induced HOXB activation which is operative in leukemia cells-of-origin and persists in established tumors where it defines a novel subset of patients distinct from other known genetic subtypes and with poor clinical outcome. We show further that anterior HOXB genes are specifically activated in human T-ALL by an epigenetic mechanism and confer growth advantage in both pre-leukemia cells and established clones.

ORGANISM(S): Homo sapiens

PROVIDER: GSE130743 | GEO | 2019/05/07

REPOSITORIES: GEO