Single cell RNA sequencing of murine liver CD45+ mononuclear cells in HBs-HepR mouse model

ABSTRACT: We used immunocompetent Fah-/- mice as the recipients and adoptively transferred HBsAg+ hepatocytes from HBs-Tg mice to replace the recipient hepatocytes (HBs-HepR). HBs-HepR mice maintained persistent HBsAg expression with chronic hepatitis and spontaneous liver fibrosis, and eventually developed HCC with a prevalence of 100%.

ORGANISM(S): Mus musculus

PROVIDER: GSE130880 | GEO | 2020/04/28

REPOSITORIES: GEO