Project description:We assessed whether human transcripts expressed in an aneuploid mouse that carries human chromosome 21 (HsChr21) are spliced in a human-specific or mouse-specific fashion. In almost all cases, human-specific alternative splicing is maintained in the mouse nucleus. Species-specific splicing therefore appears to be primarily directed by cis-acting elements, rather than changes in the levels or activities of trans-acting factors. Approximately 485 million Illumina 50-nt sequence reads were generated for brain and liver tissues from normal human, Tc0 (wildtype) mouse and Tc1 mouse strains. Sequence reads were mapped to splice junctions and %in levels were estimated.

2012-12-01 | E-GEOD-31454 | biostudies-arrayexpress

Cis-acting polymorphisms affect complex traits through modifications of microRNA regulation pathways.

Project description: Not available

| S-EPMC3350471 | biostudies-literature

Species-specific splicing differences are primarily governed by changes in cis-acting sequences

2012-12-01 | GSE31454 | GEO

cis-acting sequences required for coronavirus infectious bronchitis virus defective-RNA replication and packaging.

Project description: Not available

| S-EPMC113905 | biostudies-literature