Three-dimensional genome restructuring across timescales of activity-induced neuronal gene expression

ABSTRACT: Post-mitotic neurons in the mammalian brain form synapses that dynamically remodel throughout an individual’s lifetime to encode learning and memory. Here, we create high-resolution genome folding maps in >12 Megabases around IEGs and synaptic genes and find that 12% of long-range looping interactions are induced de novo during cortical neuron activation.

ORGANISM(S): Mus musculus

PROVIDER: GSE131025 | GEO | 2020/05/27

REPOSITORIES: GEO