Genomics

Dataset Information

0

Gene expression analysis of micoRNA-221 overexpressing transgenic mice livers with and without metformin intervention upon chronic liver injury induced by carbon tetrachloride


ABSTRACT: Metformin is a hypoglycaemic agent used to treat type 2 diabetes mellitus (DM2) patients, with a broad safety profile. Since previous epidemiological studies had shown that incidence of hepatocellular carcinoma (HCC) decreased significantly in metformin treated DM2 patients, we hypothesized that intervention with metformin could reduce the risk of neoplastic transformation of hepatocytes. HCC is the most common primary liver malignancy and it generally originates in a background of liver fibrosis and cirrhosis. In the present study, we took advantage of a transgenic mouse (TG221) characterized by microRNA-221 overexpression, with cirrhotic liver background induced by chronic administration of carbon tetrachloride (CCl4). This mouse model develops fibrosis, cirrhosis and liver tumors that become visible in 100% of mice at 5-6 months of age.

ORGANISM(S): Mus musculus

PROVIDER: GSE131175 | GEO | 2019/06/03

REPOSITORIES: GEO

Similar Datasets

2014-02-28 | GSE27640 | GEO
| E-GEOD-15654 | biostudies-arrayexpress
| E-GEOD-27640 | biostudies-arrayexpress
2022-07-05 | GSE133969 | GEO
| E-TABM-866 | biostudies-arrayexpress
2019-08-16 | GSE129374 | GEO
| E-GEOD-40744 | biostudies-arrayexpress
2020-04-14 | GSE125975 | GEO
| phs001106 | dbGaP
2021-08-19 | MSV000088003 | MassIVE