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Cell-autonomous FLT3L shedding via ADAM10 mediates conventional dendritic cell development in mouse spleen

ABSTRACT: To characterize the changes that had occurred in splenic pre-cDCs in the absence of ADAM10, we performed RNA sequencing on sorted pre-cDC1 and 2 from the spleens of wild-type and ADAM10ΔDC mice. Unsupervised hierarchical clustering and principal component analysis of all four groups demonstrated that distinct transcriptomic changes had taken place in ADAM10ΔDC pre-cDC2, while minimal changes were observed for pre-cDC1

ORGANISM(S): Mus musculus

PROVIDER: GSE131264 | GEO | 2019/11/12

REPOSITORIES: GEO

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ADAM10 shapes myeloid antigen-presenting cell homeostasis in the splenic marginal zone

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ADAM10 shapes myeloid antigen-presenting cell homeostasis in the splenic marginal zone

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Single Cell RNA-Seq Analysis Reveals Fate Decision of Human Pre-cDC Determined by Transcription Factor Competition

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Cell-autonomous FLT3L shedding via ADAM10 mediates conventional dendritic cell development in mouse spleen.

Project description: Not available

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Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction

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Cell-autonomous FLT3L shedding via ADAM10 mediates conventional dendritic cell development in mouse spleen

Project description:Cell-autonomous FLT3L shedding via ADAM10 mediates conventional dendritic cell development in mouse spleen

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