Single-cell protein-expression map of bone marrow reveals stromal cell subset selection with stress

ABSTRACT: We identified CD73+ bone marrow stromal cells as hematopoietic niche candidates. To further validate our finding, we tested the functional role of CD73 during bone marrow transplantation using CD73-/- mice. We evaluated the transcriptome of transplanted WT hematopoietic stem and progenitor cells from WT or CD73-/- recipient mice and found changes in metabolic, cell cycle and signaling genes.

ORGANISM(S): Mus musculus

PROVIDER: GSE131305 | GEO | 2019/07/03

REPOSITORIES: GEO