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Transcritptome analysis of anterior dorsal pericardial wall (aDPW) and cardiac outflow tract (OFT) from control and Hand2flox/flox; Mef2c-AHF-Cre embryos at E9.5

ABSTRACT: We aim to explore the gene expression difference in control and Hand2 mutant embryos and potential mechnisam downstream of Hand2 involved in OFT epithelium regulation.

ORGANISM(S): Mus musculus

PROVIDER: GSE131362 | GEO | 2019/05/17

REPOSITORIES: GEO

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Transcritptome analysis of anterior dorsal pericardial wall (aDPW) and cardiac outflow tract (OFT) from control and Hand2flox/flox; Mef2c-AHF-Cre embryos at E9.5

Project description:Transcritptome analysis of anterior dorsal pericardial wall (aDPW) and cardiac outflow tract (OFT) from control and Hand2flox/flox; Mef2c-AHF-Cre embryos at E9.5

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Expression data from outflow region at E9.5

Project description:A high concentration of maternal retinoic acid (RA), the active derivative of vitamin A, is well known as a teratogenic agent which can cause developmental defects. Our previous studies have shown that the maternal administration of RA to mice within a narrow developmental window induces outflow tract (OFT) septum defects, which closely resembles human transposition of the great arteries (TGA), although the responsible factors and pathogenic mechanisms of the TGA induced by RA still remain unknown. To identify the candidate genes involved in the altered development of the OFT in RA-induce TGA model, we isolated the RNA from E9.5 control and RA-treated OFT regions, and performed a microarray analysis.

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Expression data from outflow region at E9.5

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Characterisation of the outflow tract banded heart utilising RNA sequencing to direct functional analysis

Project description:Heart development is known to be influenced by haemodynamics, however the effects of abnormal load on gene expression are not clearly defined. To determine the hearts transcriptional response to stress, a model of haemodynamic alteration, outflow tract (OFT) banding, was employed in the chick embryo at HH21. Stereological and expression analysis were performed at HH29, with targeted expression studies at HH35. We defined a phenotype of left sided heart dilation and performed RNA sequencing on OFT-banded hearts compared to Sham controls. Globin transcripts were depleted in the RNA during library preparation, and 28 differentially expressed genes were identified. Expression appeared to represent a mechanism of cardioprotection with calcium sequestering, metabolic and developmental genes highlighted. Significant reductions in apoptosis were also seen. We have presented a model of left sided dilation in OFT-banded hearts and found differential expression of genes that may be associated with stress and maintaining cardiac output.

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Nkx2.5 regulates Jarid2 during outflow tract morphogenesis

Project description:The transcription factor Nkx2.5 is required for specification of pharyngeal arch second heart field (SHF) progenitors that contribute to outflow tract (OFT) and right ventricle (RV) formation. Multiple sets of microarray data were analyzed to identify genes that are candidate targets of Nkx2.5 in the second heart field. These sets are: 1) publicly available data for cardiothoracic tissue from E9.5 Nkx2.5 wild-type, heterozygous and homozygous embryos; 2) an analysis of mouse E10.5 pharyngeal arch tissue; 3) an analysis of mouse E12.5 heart tissue; and 4) a temporal analysis of the cardiogenic cell line P19CL6. This combined analysis identified 11 genes (Lrrn1, Elovl2, Safb, Slc39a6, Khdrbs1, Hoxb4, Fez1, Ccdc117, Jarid2, Nrcam, and Enpp3) expressed in SHF-containing pharyngeal arch tissue whose regulation is dependent on Nkx2.5 expression. Refer to individual Series

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