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The effects of chemokines CCL2/7 on MDA-MB-231-FOXC1 cells

ABSTRACT: Our preliminary studies performed in vitro show that MDA-MB-231-FOXC1 cell, which were used to mimic the lung-colonizing triple-negative breast cancer cells, was an indispensable component for the induction of migration and tube formation of lung endothelial cells. Moreover, our results further show that mouse lung fibroblast-derived chemokines CCL2/7 act on MDA-MB-231-FOXC1 cells, which mediates the migration and tube formation of lung endothelial cells in vitro. To understand the signaling pathways activated by CCL2/7 in MDA-MB-231-FOXC1 cells, we performed RNA-Seq assay.

ORGANISM(S): Homo sapiens

PROVIDER: GSE131383 | GEO | 2019/05/18

REPOSITORIES: GEO

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