Transcriptomic alterations in ferroptotic murine embryonic fibroblasts

ABSTRACT: Alterations of metabolic and biological processes occur in ferroptotic cells. We analyzed transcriptional responses of murine embryonic fibroblasts (MEFs) exposed to a ferroptosis inducer erastin. We found that  a set of genes related to protection against oxidative stress was induced upon ferroptosis and Bach1 promoted ferroptosis by repressing a set of these genes involved in synthesis of glutathione or metabolism of intracellular labile iron. Our findings suggests that ferroptosis is programmed at transcriptional level and Bach1 works as a controller in setting a threshold of ferroptosis.

ORGANISM(S): Mus musculus

PROVIDER: GSE131444 | GEO | 2019/11/15

REPOSITORIES: GEO