Comparative DNA methylomic analyses reveal insight into potential origins of novel monocyte epigenetic biomarkers of insulin resistance

ABSTRACT: Genome wide DNA methylation profiling of monocytes from insulin sensitive and insulin resistant HIV-infected patients. The Illumina Infinium Human Methylation 450k Beadchip was used to obtain DNA methylation profiling across 450,000+ CpGs. Samples included monocytes from 37 HIV-infected individuals, of which 14 were insulin resistant and 23 were insulin sensitive, monocytes from 9 HIV-seronegative individuals, of which 4 were insulin sensitive and 5 insulin resistant, and FACS monocyte subsets (classical, intermediate, and non-classical monocytes) from two healthy donors.

ORGANISM(S): Homo sapiens

PROVIDER: GSE131627 | GEO | 2019/06/25

REPOSITORIES: GEO