IL-6 mediated transcriptional programming of CD4+ T cells in early rheumatoid arthritis

ABSTRACT: We hypothesised that sustained exposure of naïve CD4+ T cells to IL-6 might imprint them with a distinct transcriptional programme, whose molecular and functional consequences following subsequent TCR ligation was relevant to disease development. Preexposure of healthy naïve CD4+ T-cells to pathophysiological levels of the cytokine caused induction of STAT3 target genes known to discriminate RA patients from disease controls in the clinic. After TCR stimulation IL-6 pre-exposed cells exhibited enhanced proliferative capacity, activation and a propensity towards Th1 differentiation, compared to non-exposed cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE131866 | GEO | 2019/05/29

REPOSITORIES: GEO