Genomics

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Early Life Stress Restricts Translational Reactivity in CA3 Neurons Associated with Altered Stress Response in Adulthood


ABSTRACT: Using a protocol of chronic early-life stress (ELS) induced by limited bedding and nesting material followed by acute-swim stress (AS) in adulthood, we show that mice with a history of ELS display a blunted CORT response to AS, altered levels of the repressive histone marker H3K9me3 in several hippocampal regions, and a restricted translational response to stress in CA3 neurons Overall design: Examination of the HPA, genetic, and epigenetic effects of AS in the hippocampus of control mice and mice subjected to ELS ELS = Early Life Stress, AS/FST = Acute Stress, Forced Swim Test

INSTRUMENT(S): Illumina HiSeq 2500 (Mus musculus)

ORGANISM(S): Mus musculus  

SUBMITTER: Nathan Einhorn  

PROVIDER: GSE131972 | GEO | 2019-05-31

REPOSITORIES: GEO

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GSE131972_ELS_RLog_Counts.xlsx Xlsx
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