Programmable RNA N6-methyladenosine editing by CRISPR-Cas9 conjugates

ABSTRACT: We engineered m6A methyltransferase or demethylases with CRISPR-Cas9 to achieve site-specific editing of m6A. The resultant m6A editors can be programmed with a guide RNA, allowing functional comparison of single site methylation in different mRNA regions.

ORGANISM(S): Homo sapiens

PROVIDER: GSE132051 | GEO | 2019/06/01

REPOSITORIES: GEO