Identification of novel AR and O-GlcNAc co-regulated genes in prostate cancer cells

ABSTRACT: Androgen receptor (AR) plays a central role in the development of prostate cancer. Increased expression of O-GlcNAc transferase (OGT) and O-GlcNAcylation are also implicated in metastatic prostate cancer. Increased O-GlcNAcylation in prostate cancer cells is associated with poor prognosis in patients. In this study, we employed chromatin immunoprecipitation coupled with massive parallel sequencing (ChIP-seq) to identify AR and O-GlcNAc binding sites in an attempt to identify novel co-regulatory mechanisms, biomarkers/druggable targets.

ORGANISM(S): Homo sapiens

PROVIDER: GSE132073 | GEO | 2022/06/24

REPOSITORIES: GEO