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Changes in total RNA in BK deficient mice after 4h sleep deprivation [pools]

ABSTRACT: Animals deficient for the alpha subunit of the large conductance calcium dependent potassium channel (BK) were sleep deprived for 4 hours and compared to wildtype littermates as well as animals (wildtype littermate and BK deficient) left undisturbed for the same time.

ORGANISM(S): Mus musculus

PROVIDER: GSE132075 | GEO | 2019/07/31

REPOSITORIES: GEO

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Changes in total RNA in BK deficient mice after 4h sleep deprivation [individuals]

Project description:Animals deficient for the alpha subunit of the large conductance calcium dependent potassium channel (BK) were sleep deprived for 4 hours and compared to wildtype littermates as well as animals (wildtype littermate and BK deficient) left undisturbed for the same time.

2019-07-31 | GSE132074 | GEO

Changes in total RNA in BK deficient mice after 4h sleep deprivation [pools]

Project description:Changes in total RNA in BK deficient mice after 4h sleep deprivation [pools]

| PRJNA545848 | ENA

Changes in total RNA in BK deficient mice after 4h sleep deprivation

Project description:Changes in total RNA in BK deficient mice after 4h sleep deprivation

| PRJNA545846 | ENA

Changes in total RNA in BK deficient mice after 4h sleep deprivation [individuals]

Project description:Changes in total RNA in BK deficient mice after 4h sleep deprivation [individuals]

| PRJNA545847 | ENA

Molecular analyses of antifibrotic effect of BK channel activatior on rat livers in fibrosis

Project description:Liver fibrosis is a high-morbidity and high-mortality chronic disease throughout the world without any satisfying treatment Large-conductance Ca2+- and voltage-activated K+ (Slo1, BK) channels are widely expressed in human body and important for numerous physiological processes. Previous studies have shown that BK channels are expressed in HSCs of patients with liver fibrosis and they are involved in contraction/relaxation of the HSCs To investigate the molecular mechanism of antifibrotic effect of BK channel opener rottlerin using in vivo fibrosis models. transcriptomic analyses of differential expression genes in livers from rats of vehicle, CCl4 and CCl4 combined with rottlerin treatment were for discrimination. The RNA samples were extracted from three samples of each group for microarray profiling and performed in Affymetrix Rats Genome 230 2.0 arrays for gene expression profiling analysis, which contained 31 042 probe sets. The biotinylated cRNA targets were hybridized with the microarray. After hybridization, arrays were stained in the Fluidics Station 450 and scanned on the Affymetrix Scanner 3000. The microarray experiments were performed by following the protocol of Affymetrix Inc at Shanghai Biotechnology Corporation. Under the criteria fold change > 1.5 or < 0.67, we obtained 10672 differential expressed genes (DEGs) between CCl4 and CCl4 combined with rottlerin treatment group, and the data was applied to further analysis.

2019-11-07 | GSE139994 | GEO

Changes in total RNA in BK deficient mice after 4h sleep deprivation

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-07-31 | GSE132076 | GEO

Burkholderia sp. Bk strain:Bk

Project description:Bk Burkholderia sp., Draft Genome sequencing and assembly

| PRJNA361918 | ENA

Transcription profiling of human endothelial cells after 40 h and 24 h exposure to BK virus

Project description:Investigate the effect of 40 h and 24 h exposure to BK virus on human endothelial cells.

2006-02-09 | E-BASE-3 | biostudies-arrayexpress

BK-8_plant_trnLgh_sedaDNA

Project description:Plant-derived sedimentary ancient DNA metabarcoding of permafrost core BK-8

| PRJEB39455 | ENA

Expression data from sleep deprivation experiment in mouse hippocampus

Project description:We used microarrays to detail the global programme of gene expression underlying the effect of sleep deprivation in the mouse hippocampus and identified distinct classes of regulated genes during this process. Hippocampal tissue was taken from sleep deprived mice and time-matched non-sleep-deprived control animals that were left undisturbed in their home cages during the sleep deprivation period for a total of 8 and 9 replicates per group. RNA was isolated and cDNA was synthesized from hippocampal tissue, and the sample from each animal was hybridized to a separate Affymetrix Mouse 430_2 microarray

2012-09-06 | E-GEOD-33302 | biostudies-arrayexpress

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