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Phospho-antibody microarray analyses for islets of control and Mettl14 knock-out mice

ABSTRACT: β-cell specific Mettl14 knock-out mice display reduced N6-methyladenosine (m6A) levels and recapitulate human Type II diabetes (T2D) islet phenotype with early diabetes onset and mortality secondary to decreased β-cell proliferation and insulin degranulation. To gain insights into the role of m6A in regulating the IGF1/insulin -> AKT - > PDX1 pathway and to dissect the signaling networks modulating AKT phosphorylation, we subjected freshly isolated islets from control and Mettl14 knock-out mice to phospho-antibody microarrays.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE132111 | GEO | 2019/08/09

REPOSITORIES: GEO

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