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TGFβ signaling in retinal tissue repair [Mus Musculus]

ABSTRACT: In mammals, retinal damage is followed by Müller glia cell activation and proliferation. While retinal gliosis persists in adult mammals after an insult or disease, some vertebrates, including zebrafish, have the capacity to regenerate. We believe we are the first group to show that gliosis is a fibrotic-like process in mammals’ eyes caused by differential activation of canonical and non-canonical TGFβ signaling pathways.

ORGANISM(S): Mus musculus

PROVIDER: GSE132140 | GEO | 2019/11/03

REPOSITORIES: GEO

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TGFβ signaling in retinal tissue repair [Danio Rerio]

Project description:In mammals, retinal damage is followed by Müller glia cell activation and proliferation. While retinal gliosis persists in adult mammals after an insult or disease, some vertebrates, including zebrafish, have the capacity to regenerate. We believe we are the first group to show that gliosis is a fibrotic-like process in mammals’ eyes caused by differential activation of canonical and non-canonical TGFβ signaling pathways.

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The Rax homeoprotein in Müller glial cells is required for homeostasis maintenance of the postnatal mouse retina

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