Hierarchy of mono- and bi-allelic TP53 alterations in Multiple Myeloma cell fitness

ABSTRACT: Comparison of the TP53 wild-type myeloma cell line AMO1 with the CRISPR/Cas9 engineered AMO1 cell line named UMC901. UMC901 harbors bi-allelic alterations to TP53: TP53 del/mut. Analysis of impact of TP53 alterations on gene transcription and identification of affected pathways by transcriptome-wide differential gene expression analysis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE132340 | GEO | 2019/08/06

REPOSITORIES: GEO