Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina MiSeq (Escherichia coli str. K-12 substr. MG1655)
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655
SUBMITTER: Anand Sastry
PROVIDER: GSE132442 | GEO | 2019-06-11
REPOSITORIES: GEO
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GSE132442_fpkm_42c.csv.gz | Csv |
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Sandberg Troy E TE Pedersen Margit M LaCroix Ryan A RA Ebrahim Ali A Bonde Mads M Herrgard Markus J MJ Palsson Bernhard O BO Sommer Morten M Feist Adam M AM
Molecular biology and evolution 20140710 10
Adaptive laboratory evolution (ALE) has emerged as a valuable method by which to investigate microbial adaptation to a desired environment. Here, we performed ALE to 42 °C of ten parallel populations of Escherichia coli K-12 MG1655 grown in glucose minimal media. Tightly controlled experimental conditions allowed selection based on exponential-phase growth rate, yielding strains that uniformly converged toward a similar phenotype along distinct genetic paths. Adapted strains possessed as few as ...[more]