MTORC1 controls a dynamic program of TOP mRNA translation via LARP1

ABSTRACT: LARP1 has been proposed to control the translation of TOP mRNAs downstrteam of mTORC1. Here we used ribosome profiling to analyze transcriptome-wide changes in translation following mTOR inhibition in wild-type HEK-293T cells and cells where LARP1 (sgLARP1) or LARP1 and its homologue LARP1B (sgLARP1/1B) have been deleted using CRISPR/Cas9.

ORGANISM(S): Homo sapiens

PROVIDER: GSE132703 | GEO | 2020/02/12

REPOSITORIES: GEO