Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptome analysis of B cell lymphomas in several c-myc Igh transgenic mice

ABSTRACT: Investigation of B cell lymphomas (IgM+ IgD+) located in various places (lung, mesenteric lymph nodes,…) of three different c-myc Igh transgenic mice. Insertion of c-myc in 5' to Emu (cr), in 5' to Cmu with Emu deletion (hv), and in Calpha (co).

ORGANISM(S): Mus musculus

PROVIDER: GSE132721 | GEO | 2020/01/21

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

SmallRNA-SEQ of mutants B cell for IgH 3'RR and Emu

Project description:SmallRNA-SEQ of mutants B cell for IgH 3'RR and Emu

2017-06-13 | GSE90759 | GEO

RNA-SEQ of mutants B cell for IgH 3'RR and Emu

Project description:RNA-SEQ of mutants B cell for IgH 3'RR and Emu

2017-06-13 | GSE90758 | GEO

Transcriptome analysis of B cell lymphomas in several c-myc Igh transgenic mice

Project description:Transcriptome analysis of B cell lymphomas in several c-myc Igh transgenic mice

| PRJNA548805 | ENA

IGH VDJ-RNA-seq of circulating plasma cells at day zero and seven relative to experimental vaccination dosing

Project description:IGH VDJ-RNA-sequencing of CD19+IgD-CD27+CD71+CD38+CD20- circulating plasma cells prior to vaccination (day 0) and seven (day 63) days after the third vaccination.

2019-06-01 | GSE131090 | GEO

RNA-SEQ on resting (R) and stimulated (S) B cells from several IgH 3'RR mutant models

2016-03-02 | GSE76217 | GEO

The class-specific BCR tonic signal modulates lymphomagenesis in a transgenic model of c-myc transgene deregulation.

Project description:c-myc-3'RR mice developed Burkitt like lymphoma (IgM and IgD positive cells). We wished to study lymphomagenesis in mice carrying a modified B cell receptor with a higher level of tonic signal. The c-myc-3'RR transgene was introduced in a background with an IgH mutation that replaces IgM with IgA expression. Lymphoma arising in double mutant animals mostly carried the phenotype of activated cells, often expressing CD43, and in 10% of cases carrying a plasma cell phenotype. BCR tonic signal appears as a direct modulator of B cell malignancy phenotype. Burkitt lymphoma (BL) from 4 c-myc-3'RR mice, anaplastic (ANA) lymphoma from 4 c-myc-3'RR mice, CD43 negative lymphoma from 4 c-myc-IgA mice and CD43 positive lymphoma from 4 c-myc-IgA mice were investigated.

2012-02-01 | E-GEOD-32229 | biostudies-arrayexpress

RNA-SEQ on resting (R) and stimulated (S) B cells from several IgH 3'RR mutant models

Project description:We evaluated by RNA-seq obveral transcripts in B cells (resting and activated for 2 days with LPS) sorted from several KO mice models devoid of portion or all the IgH 3' Regulatory Region One RNA-seq point was realized per condition (resting or stimulated) and per genotype. Each point corresponds to a pool of equivalent number of B cells sorted from 4 animals

2016-03-02 | E-GEOD-76217 | biostudies-arrayexpress

Global expression profiling of treatment-induced senescence in mouse Emu-myc B-cell lymphomas

Project description:Therapy-induced senescence (TIS) is a DNA damage-triggered irreversible cell-cycle block that terminates further expansion of (pre-)malignant lesions. Utilizing the Eµ-myc transgenic mouse lymphoma model (apoptosis protected by retroviral Bcl2-overexpression), we sought to elucidate the biological properties, long-term fate of senescent tumor cells and their impact on the microenvironment. We used global gene expression profiling by microarrays to gain insight into the molecular program underlying the treatment-induced senescence in Emu-myc transgenic B-cell lymphomas (apoptosis protected by Bcl2 overexpression), which robustly enter senescence in response to DNA-damaging anticancer agents such as Adriamycin (ADR).

2020-12-31 | GSE38285 | GEO

The class-specific BCR tonic signal modulates lymphomagenesis in a transgenic model of c-myc transgene deregulation.

2012-02-01 | GSE32229 | GEO

Plasmodium falciparum IGH-CR14

Project description:Plasmodium falciparum IGH-CR14

| PRJNA33119 | ENA