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Ad-HER-wt and Ad-HER2-ki infected HMECs

ABSTRACT: As an oncogene, use of HER2 vaccines in humans requires the development of HER2 immunotherapies with maximal immunologic potential, but minimal oncologic potential. To address these issues, we developed a recombinant adenoviral vector expressing a mutated HER2 inactivated for kinase function (Ad-HER2-ki). Ad-HER2-ki was highly expressed, but non-phosphorylated and elicited minimal transcription dysregulation in primary cells. In contrast, Ad-HER2-wt elicited a strong oncogenic signature associated with tumorigenesis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE13274 | GEO | 2008/11/15

SECONDARY ACCESSION(S): PRJNA109591

REPOSITORIES: GEO

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