Expression analysis to identify inducible genes in T cells

ABSTRACT: Expression microarrays were employed to identify genes induced by phorbol ester and ionomycin stimulation of EL4 cells. EL4 is a murine T cell line. To identify induced genes that were independent of new protein synthesis cells were pre-treated with cycloheximide. This expression study was used in conjunction with histone acetylation ChIP-chip to determine if inducible genes had a specific histone acetylation profile and whether the acetylation profile differed for genes with different kinetics of induction. Keywords: drug treatment comparison

ORGANISM(S): Mus musculus

PROVIDER: GSE13278 | GEO | 2009/06/01

SECONDARY ACCESSION(S): PRJNA114013

REPOSITORIES: GEO