SLIRP mediated rRNA 2'-O-methylation

ABSTRACT: SLIRP is a versatile protein that can interact with stem-loop structure in RNA and with G quadruplex DNA. By using a quantitative proteomic experiment, we found that SLIRP interacts with the majority of the human helicase proteome. We found that these interactions facilitate 2'-O-methylation of rRNA and promote protein translation. Hence, we uncovered a novel function of SLIRP protein and offered novel mechanistic insights into its function as a RNA chaperone and into the regulation of 2'-O-methylation of rRNA.

ORGANISM(S): Homo sapiens

PROVIDER: GSE132789 | GEO | 2019/06/24

REPOSITORIES: GEO