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Array CGH analysis in primary human renal tumors, categorized by VHL genotype and HIF-alpha expression


ABSTRACT: Human renal cell carcinomas (RCC) have differential expression of HIF-1alpha and HIF-2alpha, depending on VHL genotype and other events. Here, we have divided a series of RCC samples based on HIF-alpha expression, in order to examine levels of genomic DNA aberration. Keywords: Patient Sample Study Overall design: A total of 57 frozen RCC samples were stained for HIF-1alpha and HIF-2alpha, and genotyped for VHL. 10 VHL-deficient/HIF-1alpha+/HIF-2alpha+ and 11 VHL-deficient/HIF-2alpha+ tumors were selected for array CGH.

INSTRUMENT(S): Illumina HumanHap550-Duov3 Genotyping BeadChip (HumanHap550-2v3_B)

ORGANISM(S): Homo sapiens  

SUBMITTER: Bradley Wubbenhorst   

PROVIDER: GSE13282 | GEO | 2008-12-27

SECONDARY ACCESSION(S): PRJNA109603

REPOSITORIES: GEO

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