Response of synovial fibroblasts to TNFα and IL6/sIL6R

ABSTRACT: Synovial fibroblasts (SF) are the main mesenchymal cell type constitutive in human synovial tissue. SF contribute to the homeostasis of normal joints by synthesizing extracellular matrix components and secreting the specific components of synovial fluid. SF are essential players in RA pathophysiology, they are the primary source of IL6 in the RA synovium contributing to perpetuate the inflammation in the joint. We used microarrays analysis to characterize the effector pro-inflammatory response of SF to TNFα and IL6/sIL6R signaling.

ORGANISM(S): Homo sapiens

PROVIDER: GSE132830 | GEO | 2021/06/01

REPOSITORIES: GEO