Transcriptome analysis of differential expressed genes in B cell lymphomas from myeloid-specific Beclin-1 (Becn1ΔM) KO mice compared to (wild type) WT cervical lymph node controls.

ABSTRACT: We report that myeloid-deficient Becn1 (Becn1ΔM) mice develop spontaneous B cell lymphoma. To determine the gene expression profiling of the tumor, we extracted total RNA from cervical lymph node tumors for RNA-seq, and found an upregulation of genes coding for inflammatory and B cell-stimulating molecules and a downreglation of cell junction molecules related to leukocyte transendothelial migration.

ORGANISM(S): Mus musculus

PROVIDER: GSE132899 | GEO | 2019/12/31

REPOSITORIES: GEO