The oncogenic action of NRF2 depends on de-glycation by Fructosamine-3-kinase (FN3K)

ABSTRACT: We show that NRF2 activation drives hepatocellular carcinoma development in vivo. Moreover, NRF2 undergoes glucose dependent modification called glycation and requires the de-glycating enzyme FN3K to maintain NRF2' oncogenic functions.

ORGANISM(S): Mus musculus

PROVIDER: GSE133160 | GEO | 2019/06/22

REPOSITORIES: GEO