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PRC2 activates interferon-stimulated genes indirectly by repressing miRNAs in glioblastoma

ABSTRACT: Purpose: The goal of this study was to identify genes induced upon type I and II interferon response and how loss of PRC2/EZH2 impacts their induction. Methods: mRNA-seq from cells treated with universal type I IFN alpha/beta or IFN gamma. miRNA-seq from GBM-derived tumor samples.

ORGANISM(S): Homo sapiens

PROVIDER: GSE133211 | GEO | 2019/08/30

REPOSITORIES: GEO

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