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FMRP facilitates the nuclear export of N6-methyladenosine-containing mRNAs

ABSTRACT: FMRP facilitates the nuclear export of N6-methyladenosine-containing mRNAs.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE133724 | GEO | 2019/11/21

REPOSITORIES: GEO

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FMRP facilitates the nuclear export of N6-methyladenosine-containing mRNAs

Project description:FMRP facilitates the nuclear export of N6-methyladenosine-containing mRNAs

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Project description:N6-methyladenosine (m6A) is the most common internal modification in eukaryotic messenger RNA (mRNA). The effects of this reversible cheimcal modification are mediated in part by methyl-specific RNA binding protein 'readers' of the YTH family. In this study we present the function of YTHDC1 (YT521) in promoting the export of mRNA from the nucleus to the cytoplasm. Additionally, we identify a role for YTHDC1 in exon retention in mouse embryonic stem cells (mESCs).

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YTHDF3 improves translation initiation of mRNAs with N6-methyladenosine methylation at 5’ untranslated region by facilitating eIF2AK2 recruitment in oxaliplatin-resistant colorectal cancer - RIP-seq dataset

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2022-02-04 | E-MTAB-11321 | biostudies-arrayexpress

YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs.

Project description: Not available

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YTHDF3 improves translation initiation of mRNAs with N6-methyladenosine methylation at 5’ untranslated region by facilitating eIF2AK2 recruitment in oxaliplatin-resistant colorectal cancer

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N6-methyladenosine (m6A) profiling in 60 YRI LCLs

Project description:N6-methyladenosine (m6A), the most abundant messenger RNA (mRNA) modification, has emerged as a critical post-transcriptional mechanism that regulates various aspect of mRNA metabolism including pre-mRNA processing, mRNA export, mRNA stability and translation efficiency. However the genetics basis of m6A is largely unexplored. In this work, we mapped m6A-QTLs in 60 LCLs and used the resulting tens of thousands of QTLs to provide insights to m6A biology and its contribution to human complex trait.

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The RNA-binding protein FMRP facilitates the nuclear export of <i>N</i><sup>6</sup>-methyladenosine-containing mRNAs.

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N6-Methyladenosine methylation profile in rat H9C2 cardiomyocytes under the hypoxic stress

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