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RNA-sequencing data from PLC/PRF/5 cells with NC or USP22 knockdown (shUSP22) under hypoxic condition

ABSTRACT: We use RNA-sequencing to evaluate the effect of USP22 knockdown on the gene changes in HCC cells

ORGANISM(S): Homo sapiens

PROVIDER: GSE133858 | GEO | 2021/07/05

REPOSITORIES: GEO

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RNA-sequencing data from PLC/PRF/5 cells with NC or USP22 knockdown (shUSP22) under hypoxic condition

Project description:RNA-sequencing data from PLC/PRF/5 cells with NC or USP22 knockdown (shUSP22) under hypoxic condition

| PRJNA552817 | ENA

RNA-seq data for USP22 knockdown in Huh7 cells

Project description:USP22 plays oncogenic roles and in order to identify the molecular mechanism of USP22 to promote tumorigenesis, RNA-seq was performed on Huh7 cells with or without USP22.

2021-04-10 | GSE171225 | GEO

mRNA-seq of HCT116 USP22 knockdown cells

Project description:This analysis identifies genes which are affected in HCT116 cells upon USP22 knockdown

2019-10-26 | E-MTAB-7393 | biostudies-arrayexpress

mRNA-seq of SW480 USP22 knockdown cells

Project description:This analysis identifies genes which are affected in SW480 cells upon siRNA-mediated USP22 knockdown

2019-12-05 | E-MTAB-8214 | biostudies-arrayexpress

mRNA-seq of SW837 USP22 knockdown cells

Project description:This analysis identifies genes which are affected in SW837 cells upon siRNA-mediated USP22 knockdown

2019-12-06 | E-MTAB-8215 | biostudies-arrayexpress

mRNA-seq of MCF10A USP22 knockdown cells

Project description:This analysis identifies genes which are affected in MCF10A cells upon siRNA-mediated USP22 knockdown

2019-12-06 | E-MTAB-8247 | biostudies-arrayexpress

Transcriptional profiling of Usp22-WT and Usp22-KO pancreatic tumor cells

Project description:RNA-seq analysis of sorted Usp22-WT and Usp22-KO tumor cells from subcutaneously implanted mouse pancreatic tumors

2019-11-08 | GSE140088 | GEO

ACC-MESO1 cells: Control shRNA vs USP22 shRNA

Project description:USP22 plays oncogenic role and in order to study molecular mechanism of USP22 to promote tumorigenesis, microarray analysis was performed on USP22 knockdowned cells.

2018-10-01 | GSE104929 | GEO

USP22 controls necroptosis by regulating receptor interacting protein kinase 3 ubiquitination

Project description:Dynamic control of ubiquitination by deubiquitinating enzymes is essential for almost all biological processes. Ubiquitin-specific peptidase 22 (USP22) is part of the SAGA complex and catalyzes the removal of monoubiquitination from histone H2B, thereby regulating gene transcription. However, novel roles for USP22 have recently emerged, such as tumor development and cell death. Apart from apoptosis, the relevance of USP22 in other programmed cell death pathways still remains unclear. Here, we describe a novel role for USP22 in controlling necroptotic cell death in a variety of tumor cell lines. Loss of USP22 expression significantly delays TNF/Smac mimetic/zVAD.fmk (TBZ)-induced necroptosis, without affecting TNF-mediated NF-B activation or extrinsic apoptosis. Mass-spectrometric ubiquitin remnant profiling identified lysine 518 of Receptor-interacting protein kinase 3 (RIPK3) as USP22-dependent ubiquitination target during necroptosis induction. Mutation of K518 in RIPK3 reduced necroptosisassociated RIPK3 ubiquitination and amplified necrosome formation and necroptotic cell death. In conclusion, we identify a novel role of USP22 in necroptosis and further elucidate the relevance of ubiquitination as crucial regulator of necroptotic cell death.

2021-05-03 | PXD020909 | Pride

Usp22 depletion in E14 mouse ESCs

Project description:Mouse ESCs depleted of the epigenetic modifying enzyme Usp22 fail to differentiate properly. Ectopic expresison of Usp22 results in spontaneous differnetiation. In order to understand the transcriptional program underlying this biological defect, whole genome expression analysis was performed. E14 mESCs were infected with lentivirus containing shRNA targeting Usp22 or control (Luc). RNA was extracted from both samples and subjected to expression analysis by affymetrix array.

2013-05-15 | E-GEOD-42934 | biostudies-arrayexpress

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